Metomidate
API Manufacturer
in India & Germany
Afro Pharmacy is a trusted name in Active Pharmaceutical Ingredient manufacturing. Since 2021, we produce pharmaceutical-grade Metomidate API from our certified facilities in India and Germany — delivering consistent purity, regulatory compliance, and supply reliability to global pharmaceutical and veterinary markets.
Quick Specifications
Metomidate — API Manufacturer in India & Germany
Afro Pharmacy, a trusted and growing name among API Bulk Drug Manufacturers since 2021, specialises in producing high-purity Metomidate API that meets stringent international standards of quality, consistency, and safety. Metomidate Hydrochloride is an imidazole-based, non-barbiturate hypnotic and sedative agent that works by activating and modulating GABA-A receptors — the same receptor class targeted by several major anaesthetic agents. It is structurally related to Etomidate and shares its core imidazole backbone and mechanism of action.
🏭 Afro Pharmacy manufactures Metomidate API from two independently certified sites — India and Germany — enabling regulatory flexibility, supply redundancy, and seamless access to both Asian and European markets.
Metomidate HCl API —
Pharmaceutical & Veterinary Grade
Afro Pharmacy’s Metomidate Hydrochloride API is synthesised and quality-tested across our WHO-GMP certified India facility and EU GMP certified Germany facility. Each batch is released only after passing full pharmacopoeia-compliant analytical testing — ensuring the consistent purity and safety required by pharmaceutical formulators, veterinary drug manufacturers, and research institutions globally.
| Product Name | Metomidate Hydrochloride |
| Synonyms | Aquacalm; Methyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate HCl |
| CAS Number | 35944-74-2 |
| Molecular Formula | C₁₃H₁₄N₂O₂ · HCl |
| Molecular Weight | 266.72 g/mol |
| Pharmacopoeia | USP / BP / EP |
| Purity | ≥ 99.0% |
| Appearance | White to Off-White Crystalline Powder |
| Solubility | Soluble in water & methanol |
| Storage | 2–8°C, sealed, away from light & moisture |
| Category | Imidazole-Based Hypnotic / Sedative Agent |
| Manufacturing Sites | 🇮🇳 India 🇩🇪 Germany |
Metomidate is commercially recognised under the brand name Aquacalm for use as an immersion anaesthetic in ornamental finfish and is a well-established veterinary and pharmaceutical research API. It produces rapid sedation and anaesthetic induction with a predictable recovery profile, making it valuable across multiple controlled applications in aquaculture, veterinary medicine, and pharmaceutical research settings.
As a reliable Metomidate API Manufacturer in India and Germany, Afro Pharmacy has invested in advanced synthesis infrastructure, multi-stage quality testing, and robust documentation frameworks aligned with USP, BP, and EP pharmacopoeia standards. Our dedicated R&D team ensures consistent batch-to-batch reproducibility, process optimisation, and full compliance with ICH Q7 Good Manufacturing Practice guidelines for Active Pharmaceutical Ingredients.
Pharmacology & Applications
Metomidate Hydrochloride is a versatile imidazole derivative with a well-characterised pharmacological profile. Its primary mechanism involves positive allosteric modulation of GABA-A receptors, producing dose-dependent sedation, hypnosis, and anaesthesia. Below is a summary of its key application areas:
| Application Area | Indication | Grade |
|---|---|---|
| Aquaculture & Fisheries | Immersion anaesthetic for ornamental finfish; stress-free handling, transportation, tagging, and biopsy procedures in Atlantic salmon, cod, halibut, and other species | Veterinary |
| Veterinary Medicine | Sedation and hypnosis in small mammals, birds, and reptiles; used in combination with other agents (e.g., fentanyl) for balanced anaesthesia in laboratory animals | Veterinary |
| Pharmaceutical Research | Reference standard for analytical method development (AMV), quality control (QC) testing, ANDA submissions, and Etomidate EP Impurity B characterisation | API / Reference |
| Cortisol Suppression Studies | Suppresses HPI axis activity and blocks cortisol production — used in research examining adrenocortical responses, stress physiology, and immunosuppression | Research |
| Preclinical Pharmacology | Evaluation of GABA-A receptor modulation, soft anaesthetic analogue studies, and development of next-generation etomidate-class compounds without adrenocortical suppression | Research |
Why Choose Afro Pharmacy?
Analytical Rigour
Every Metomidate batch is tested for assay, purity (≥99%), related substances, residual solvents, heavy metals, and microbial limits — with full CoA documentation provided.
Dual-Continent Reach
India and Germany facilities provide multi-regulatory access — covering WHO-GMP, EU GMP, and international pharmacopoeia compliance in a single supply partnership.
Full Documentation Support
We provide comprehensive regulatory documentation — DMF support, CoA, SDS, stability data, and method validation packages — to streamline your regulatory submissions.
Flexible Supply Models
From milligram reference standards to multi-kilogram commercial batches, our supply model scales to your needs with reliable lead times and consistent quality.
Contract Manufacturing
We accept long-term CMO contracts for Metomidate and related imidazole-based APIs, as well as custom synthesis of intermediates to client-specific specifications.
R&D Collaboration
Our in-house R&D team supports process development, scale-up, and method optimisation — enabling faster timelines from lab scale to commercial API production.
Our Manufacturing Sites
Our strategically located dual-site model provides Metomidate API customers with the advantage of both Asian-cost efficiency and European-regulatory precision — all under one supply partnership.
India Facility
Primary Manufacturing HubOur India facility serves as the primary production site for Metomidate API, equipped with state-of-the-art synthesis equipment, in-house analytical laboratories, and a fully documented WHO-GMP quality management system. The site supports large-scale commercial batches and shorter lead times for Asian and Middle Eastern markets.
- WHO-GMP Certified Manufacturing
- In-house HPLC & analytical QC lab
- USP, BP & EP pharmacopoeia compliance
- DMF (Drug Master File) support available
- Commercial and research-scale batch capability
- Established export to 30+ countries
Germany Facility
European Manufacturing HubOur Germany facility positions Afro Pharmacy as an EU-based Metomidate API manufacturer, offering regulatory proximity to European markets and EMA-aligned compliance pathways. This site is especially significant for customers requiring EU GMP certification and local origin documentation for European regulatory submissions.
- EU GMP Certified Manufacturing
- EMA-aligned regulatory documentation
- ISO/IEC 17025 & ISO 17034 capabilities
- Reference standard & impurity manufacturing
- Certificate of Analysis with traceability
- Serving European pharmaceutical companies directly
Our Global Presence
Afro Pharmacy supplies Metomidate API and other bulk drug ingredients to pharmaceutical companies, veterinary drug manufacturers, aquaculture product developers, and research institutions across the globe. Our dual manufacturing presence in India and Germany enables us to reach diverse markets with speed, compliance, and cost-effectiveness.
Europe
Germany, France, Netherlands, UK, Italy, Spain, Belgium, Poland, Switzerland, Nordics
MENA / GCC
Saudi Arabia, UAE, Qatar, Kuwait, Bahrain, Oman, Jordan, Egypt, Lebanon, Iraq
Southeast Asia
Malaysia, Indonesia, Philippines, Vietnam, Thailand, Myanmar, Singapore, Cambodia
South Asia
India (domestic), Bangladesh, Sri Lanka, Nepal, Pakistan, Maldives
Africa
Egypt, Nigeria, Kenya, South Africa, Morocco, Ethiopia, Ghana, Tanzania, Sudan
Americas & Others
USA, Canada, Mexico, Brazil, Colombia; export-ready for FDA regulated markets
Contact Today for Support & Solutions
Reach out to our team for pricing, regulatory documentation, stability data, or to discuss a long-term supply or contract manufacturing arrangement for Metomidate API.