Tiletamine
API Manufacturer
in India & Germany
Afro Pharmacy is a trusted name in Active Pharmaceutical Ingredient manufacturing. Since 2021, we produce pharmaceutical-grade Tiletamine API from our certified facilities in India and Germany — delivering consistent purity, regulatory compliance, and supply reliability to global pharmaceutical, veterinary, and wildlife management markets.
Quick Specifications
Tiletamine — API Manufacturer in India & Germany
Afro Pharmacy, a trusted and growing name among API Bulk Drug Manufacturers since 2021, specialises in producing high-purity Tiletamine API that meets stringent international standards of quality, consistency, and safety. Tiletamine Hydrochloride is a dissociative, non-barbiturate anaesthetic agent that exerts its pharmacological effect primarily through antagonism of N-methyl-D-aspartate (NMDA) receptors — the same receptor class targeted by ketamine and phencyclidine (PCP). Chemically, Tiletamine is 2-(ethylamino)-2-(2-thienyl)cyclohexanone, a thiophene-substituted cyclohexanone derivative that shares structural kinship with ketamine while exhibiting notably greater potency at PCP receptor binding sites.
🏭 Afro Pharmacy manufactures Tiletamine API from two independently certified sites — India and Germany — enabling regulatory flexibility, supply redundancy, and seamless access to both Asian and European markets.
Tiletamine HCl API —
Veterinary & Research Grade
Afro Pharmacy’s Tiletamine Hydrochloride API is manufactured under WHO-GMP and EU GMP conditions at our India and Germany facilities respectively. Widely known as the active anaesthetic component of Telazol®, each batch is comprehensively tested for purity, related substances, residual solvents, and microbial limits — ensuring the quality and safety required by veterinary drug formulators, wildlife management agencies, and pharmaceutical research institutions worldwide.
| Product Name | Tiletamine Hydrochloride |
| Synonyms | Telazol® component; 2-(ethylamino)-2-(2-thienyl)cyclohexanone HCl |
| CAS Number | 14176-49-9 (base) / 14176-50-2 (HCl) |
| Molecular Formula | C₁₂H₁₇NOS · HCl |
| Molecular Weight | 259.80 g/mol |
| Pharmacopoeia | USP / BP / EP |
| Purity |
≥ 98.0%
|
| Appearance | White to Off-White Crystalline Powder |
| Mechanism | NMDA Receptor Antagonist (PCP site) |
| Primary Use | Veterinary dissociative anaesthesia; wildlife immobilisation |
| Combination | Used with Zolazepam as Telazol® / Zoletil® |
| Storage | Cool, dry place; protect from light & moisture |
| Manufacturing Sites | 🇮🇳 India 🇩🇪 Germany |
Tiletamine is most widely recognised as the active anaesthetic component of Telazol®, a commercially established combination veterinary product formulated with the benzodiazepine Zolazepam. This fixed-ratio combination is extensively used for immobilisation and general anaesthesia in domestic animals and free-ranging wildlife species including bears, big cats, cervids, seals, and various exotic species. Tiletamine alone is also employed as a pharmaceutical reference standard and a controlled substance research compound, given its well-characterised receptor pharmacology and CNS activity profile.
As a reliable Tiletamine API Manufacturer in India and Germany, Afro Pharmacy has invested in advanced synthesis infrastructure, multi-stage quality testing, and robust documentation frameworks aligned with USP, BP, and EP pharmacopoeia standards. Our dedicated R&D team ensures consistent batch-to-batch reproducibility, process optimisation, and full compliance with ICH Q7 Good Manufacturing Practice guidelines for Active Pharmaceutical Ingredients.
Beyond manufacturing, Afro Pharmacy also functions as a dependable Tiletamine API Trader, providing flexible supply arrangements — from small research quantities to commercial-scale bulk orders — tailored to client-specific needs across the globe. Our dual-site supply chain ensures we maintain uninterrupted availability, even during regional operational disruptions, giving our pharmaceutical and veterinary partners the confidence they need for continuous production and research activities.
Pharmacology & Applications
Tiletamine Hydrochloride possesses a well-characterised dissociative pharmacological profile. Its primary mechanism involves non-competitive antagonism at NMDA-type glutamate receptors via binding to the PCP receptor site within the ion channel — producing dose-dependent sedation, catalepsy, and surgical anaesthesia. It exhibits significantly higher potency than ketamine at central PCP recognition sites (IC₅₀ ≈ 79 nM) and additionally influences dopaminergic neurotransmission. Below is a summary of its key application areas:
| Application Area | Indication | Grade |
|---|---|---|
| Wildlife Immobilisation | Remote injectable anaesthesia for free-ranging and captive wildlife including bears, polar bears, big cats, wolves, cervids, and marine mammals; enables safe biological sampling, tagging, translocation, and medical procedures | Veterinary |
| Companion Animal Anaesthesia | Used in combination with zolazepam (as Telazol®) for induction and short-term general anaesthesia in dogs and cats; suitable for intramuscular administration in fractious or difficult-to-handle animals | Veterinary |
| Exotic & Zoo Animal Medicine | Broad-spectrum utility across reptiles, primates, pinnipeds, and ungulates; used by zoological institutions and wildlife veterinarians for routine health examination, dental work, and surgical interventions | Veterinary |
| Pharmaceutical Research | Reference standard for analytical method development (AMV), quality control (QC) testing, NMDA receptor binding studies, dissociative pharmacology research, and impurity characterisation in ketamine-class compound development | API / Reference |
| Preclinical Neuropharmacology | Evaluation of glutamate receptor antagonism, stereotypy and ataxia models, schizophrenia pharmacology, addiction research, and development of next-generation NMDA antagonist anaesthetics with improved safety profiles | Research |
Why Choose Afro Pharmacy?
Since our establishment in 2021, Afro Pharmacy has built its reputation on pharmaceutical integrity, dual-continent manufacturing, and a client-first supply philosophy. Here is what sets us apart:
Analytical Rigour
Every Tiletamine batch is tested for assay, purity (≥98%), related substances, residual solvents, heavy metals, and microbial limits — with full CoA documentation provided.
Dual-Continent Reach
India and Germany facilities provide multi-regulatory access — covering WHO-GMP, EU GMP, and international pharmacopoeia compliance in a single supply partnership.
Full Documentation Support
We provide comprehensive regulatory documentation — DMF support, CoA, SDS, stability data, and method validation packages — to streamline your regulatory submissions.
Flexible Supply Models
From milligram reference standards to multi-kilogram commercial batches, our supply model scales to your needs with reliable lead times and consistent quality.
Contract Manufacturing
We accept long-term CMO contracts for Tiletamine and related NMDA-antagonist APIs, as well as custom synthesis of intermediates to client-specific specifications.
R&D Collaboration
Our in-house R&D team supports process development, scale-up, and method optimisation — enabling faster timelines from lab scale to commercial API production.
Our Manufacturing Sites
Our strategically located dual-site model provides Tiletamine API customers with the advantage of both Asian-cost efficiency and European-regulatory precision — all under one supply partnership.
India Facility
Primary Manufacturing HubOur India facility serves as the primary production site for Tiletamine API, equipped with state-of-the-art synthesis equipment, in-house analytical laboratories, and a fully documented WHO-GMP quality management system. The site supports large-scale commercial batches and shorter lead times for Asian, Middle Eastern, and global veterinary markets.
- WHO-GMP Certified Manufacturing
- In-house HPLC & analytical QC lab
- USP, BP & EP pharmacopoeia compliance
- DMF (Drug Master File) support available
- Commercial and research-scale batch capability
- Established export to 30+ countries
Germany Facility
European Manufacturing HubOur Germany facility positions Afro Pharmacy as an EU-based Tiletamine API manufacturer, offering regulatory proximity to European markets and EMA-aligned compliance pathways. This site is especially significant for customers requiring EU GMP certification and local origin documentation for European regulatory submissions, including controlled substance licence support.
- EU GMP Certified Manufacturing
- EMA-aligned regulatory documentation
- ISO/IEC 17025 & ISO 17034 capabilities
- Reference standard & impurity manufacturing
- Certificate of Analysis with full traceability
- Serving European pharmaceutical companies directly
Our Global Presence
Afro Pharmacy supplies Tiletamine API and other bulk drug ingredients to pharmaceutical companies, veterinary drug manufacturers, wildlife management agencies, zoological institutions, and research organisations across the globe. Our dual manufacturing presence in India and Germany enables us to reach diverse markets with speed, compliance, and cost-effectiveness.
Europe
Germany, France, Netherlands, UK, Italy, Spain, Belgium, Poland, Switzerland, Nordics
MENA / GCC
Saudi Arabia, UAE, Qatar, Kuwait, Bahrain, Oman, Jordan, Egypt, Lebanon, Iraq
Southeast Asia
Malaysia, Indonesia, Philippines, Vietnam, Thailand, Myanmar, Singapore, Cambodia
South Asia
India (domestic), Bangladesh, Sri Lanka, Nepal, Pakistan, Maldives
Africa
Egypt, Nigeria, Kenya, South Africa, Morocco, Ethiopia, Ghana, Tanzania, Sudan
Americas & Others
USA, Canada, Mexico, Brazil, Colombia; export-ready for FDA-regulated markets
Contact Today for Support & Solutions
Reach out to our team for pricing, regulatory documentation, stability data, or to discuss a long-term supply or contract manufacturing arrangement for Tiletamine API.